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There is crisis of quality in materials and life science R&D. A $20 flash memory stick is 50,000 times more reliable than a typical $500,000 research project. The implications for society are staggering. The root cause of irreproducible research is unmanaged experimental noise. One hundred years of industrial manufacturing around the world has shown that such noise can be conquered. When noise is driven out, productivity is driven up. Riffyn unites computer-aided design of experimental protocols, real-time data acquisition via mobile and IoT devices, 24/7 cloud-based analytics, and collaborative versioning to reduce error and accelerate innovation. Check out our vision: http://www.sciencemag.org/content/345/6199/855.summary